The Phoenix Protocol Dry Fasting for Rapid Healing and Radical Life Extension: Functional Immortality by August Dunning

Author:August Dunning [Dunning, August]
Language: eng
Format: epub
Published: 2022-09-15T00:00:00+00:00

Chapter 8

Aging and Age Reversal

“You are never too old to become younger!"

- Mae West

This is another complex chapter because it discusses DNA methylation. I’ll do my best to keep it simple.

Methylation is a process whereby methyl groups, a combination of carbon and hydrogen atoms (CH3), bonded to DNA at a promoter site. In genetics, a promoter site is a region along the DNA helix backbone that identifies the location to open the DNA to read a particular gene; usually near the amino acid cytosine. When methyl groups attach along the helix, they stick out like a thorn on a rose bush. When they are located at a gene promoter site, they act to repress gene transcription. This is the reason why methylation is the primary cause of aging. These methyl groups can prevent a wide range of proteins from being created, and making proteins is how we stay alive. Methylation occurs on two of the four amino acids in DNA; cytosine and adenine. In some cases, methylation is essential for tissue-specific gene expression.

Differentiated stem cells develop a stable and unique DNA methylation pattern that regulates their tissue-specific gene transcription. In this case, it’s not bad. But in the brain, for instance, when DNA is methylated as a result of environmental toxins, drug exposure or neural injury, methyl groups left at promoter sites change gene expression and mental impairment is a common side effect. In this case, it’s very bad.

Demethylation is the key to return cellular function and reverse aging.

The signs of methylation

The signs of aging are symptoms of the effects of these thorns on the DNA and its effect on the number of different proteins a cell can or can’t make. It’s seen as less elasticity in the skin, more wrinkles, failing eyesight, cognitive dysfunction, more aches and pains. Old cells can’t make all the proteins that a young cell can. That’s why old people look old. Old people have cells that have accumulated so many of these ‘thorns’ that their cells can’t function as young cells anymore.

These thorns are epigenetic markers that build up in a very linear and predictable way. The DNAm, GrimAge and AgeAcclGrim tests are lifespan predictor tests that use the accumulation of these markers to calculate how long a person has left to live.

Being able to remove these artifacts of repair is critical for maintaining tight control of protein codes that maintain cell and organ functionality. Once signs of aging are evident, a body already has billions of cells with trillions of artifacts that must be removed to restore youth. Therefore, it’s important to conduct a system-wide removal sooner than later and, unfortunately, no dietary means can achieve this level of restoration. However, dry fasting activates the cellular and autophagic repair systems that can demethylate DNA and, furthermore, target weak and damaged cells for removal altogether.[30]

There is little doubt that removing these markers is a critical step to achieve radical life extension. I will show later that if they are not removed, lifespan can’t be radically lengthened.

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